Posle dužeg korišćenja opijata, ćelije u mozgu, koje bi inače proizvodile prirodne opijate - endorfine, prestaju da funkcionišu normalno. Telo prestaje da proizvodi endorfine jer dobija opijate umesto njih. Degeneracija ovih nervnih ćelija uzrokuje fizičku zavisnost od eksternog izvora opijata. Nagli prestanak uzimanja opijata prouzrokuje apstinencijalni sindrom.
Bezbolno skidanje sa droge se vrši na ruskoj privatnoj klinici Dr Vorobjev u Beogradu.
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